Hepatic Iron Index Calculator
Here’s a comprehensive table covering everything you need to know about the Hepatic Iron Index (HII):
| Aspect | Details |
|---|---|
| Definition | A diagnostic tool used to assess iron overload in the liver. |
| Calculation | HII = Hepatic Iron Concentration (µg/g) / Age (years) |
| Units | Hepatic Iron Concentration is measured in micrograms of iron per gram of liver tissue. |
| Normal Values | Generally, a normal HII is less than 1.9. Values ≥ 1.9 suggest iron overload. |
| Indications | – Suspected hemochromatosis – Chronic liver disease – Conditions associated with iron overload |
| Interpretation | – < 1.9: No significant iron overload – 1.9 – 3.0: Possible mild overload – > 3.0: Significant iron overload, may indicate hereditary hemochromatosis or other conditions |
| Method of Measurement | Typically obtained through liver biopsy and subsequent histological analysis. |
| Limitations | – Invasive procedure (liver biopsy) – Variability due to sampling error – Not always reflective of systemic iron status |
| Associated Conditions | – Hemochromatosis – Chronic liver disease – Thalassemia – Sideroblastic anemia |
| Management of Iron Overload | – Phlebotomy (blood removal) – Iron chelation therapy (e.g., Deferoxamine) |
| Follow-Up | Regular monitoring of iron levels and liver function tests in patients with elevated HII. |
Key Points:
- The Hepatic Iron Index is particularly useful in distinguishing between normal and pathological iron levels in the liver.
- It helps guide treatment decisions in patients with iron overload conditions.
- Understanding the HII is essential for healthcare providers dealing with liver diseases and iron metabolism disorders.