Hepatic Iron Index Calculator

Hepatic Iron Index Calculator

Here’s a comprehensive table covering everything you need to know about the Hepatic Iron Index (HII):

AspectDetails
DefinitionA diagnostic tool used to assess iron overload in the liver.
CalculationHII = Hepatic Iron Concentration (µg/g) / Age (years)
UnitsHepatic Iron Concentration is measured in micrograms of iron per gram of liver tissue.
Normal ValuesGenerally, a normal HII is less than 1.9. Values ≥ 1.9 suggest iron overload.
Indications– Suspected hemochromatosis
– Chronic liver disease
– Conditions associated with iron overload
Interpretation< 1.9: No significant iron overload
1.9 – 3.0: Possible mild overload
> 3.0: Significant iron overload, may indicate hereditary hemochromatosis or other conditions
Method of MeasurementTypically obtained through liver biopsy and subsequent histological analysis.
Limitations– Invasive procedure (liver biopsy)
– Variability due to sampling error
– Not always reflective of systemic iron status
Associated Conditions– Hemochromatosis
– Chronic liver disease
– Thalassemia
– Sideroblastic anemia
Management of Iron Overload– Phlebotomy (blood removal)
– Iron chelation therapy (e.g., Deferoxamine)
Follow-UpRegular monitoring of iron levels and liver function tests in patients with elevated HII.

Key Points:

  • The Hepatic Iron Index is particularly useful in distinguishing between normal and pathological iron levels in the liver.
  • It helps guide treatment decisions in patients with iron overload conditions.
  • Understanding the HII is essential for healthcare providers dealing with liver diseases and iron metabolism disorders.

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