Physical Damage | | Heavy Gunner: +10% per rank | Combat Armor: Provides varying resistance |
| | Iron Fist: Increases unarmed damage | Power Armor: Significant physical damage resistance |
| | Armorer: Increases armor resistance | |
Energy Damage | | Demolition Expert: Increases explosives resistance | Synth Armor: Can provide energy resistance |
| | Energy Weapons: Use Energy Weapon Perks | |
Radiation Damage | | Radiation Resistance (various perks available) | RadAway: Reduces radiation damage over time |
| | Chem Resistant: 50% resistance to chem effects | Hazmat Suit: Provides high radiation resistance |
Explosive Damage | | Demolition Expert: Reduces explosive damage | Explosive Resistance Armor: Various armor sets |
| | Heavy Gunner: +10% per rank (for heavy weapons) | |
Fire Damage | | Fireproof: 50% resistance to fire damage | Fire-Resistant Armor: Various armors can provide fire resistance |
| | Chem Resistant: Reduces damage from fire-related chems | |
Cryo Damage | | Chilled: Reduces damage from freezing effects | Cold-Weather Gear: Can mitigate cryo effects |
| | Armor Mods: Some armor types have cryo resistance | |
Melee Damage | | Iron Fist: Increases melee damage dealt | Power Armor: Can reduce melee damage taken |
| | Ghoulish: Healing effects when in radiation | |